Back

Bioelectric Signal Amplifier modules

 MEA

MicroElectrode Amplifier type 695 

The PLUGSYS module MEA is a universal single-channel, easily operated microelectrode amplifier for physiological and pharmacological research. With the aid of the separate preamplifier (headstage) it permits direct measurement of intracellular or extracellular potentials. The compact PLUGSYS module incorporates extensive technology and offers, in addition to its excellent amplifier performance, also all modern extra facilities such as adjustable output filter, calibration generator, audio monitor and LED bargraph for audible and visual signal monitoring, microelectrode function test (resistance measurement), adjustable buzz frequency, capacity compensation and zero balance. Optionally the MEA can be provided with special headstages and a multi-function clamp amplifier PLUGSYS module for current clamp and voltage clamp applications.

Important note for ordering:
MEA Type 695 can not be used without headstage and is therefore always supplied with a standard headstage Type 695-1G unless otherwise specified in the order.

 

Description

Microelectrode amplifier module
Input Through separate preamplifier (headstage) for direct intracellular or extracellular potential recording. 
Input socket 8-pin Binder or Amphenol-Tuchel socket with screw lock. 
Input capacity compensation Continuously adjustable between 0 and 8 pF. 
Signal output Filtered output signal ±10 Volt corresponding to ±1 Volt input signal (gain 10x)
Internally on PLUGSYS system bus, assigned via a jumper to one of the signal lines AV-1 to AV-16.
Externally by BNC socket on the front panel.
 
Amplifier bandwidth DC to 30 kHz (-3dB). 
Output filter Low-pass in 7 steps covering 30 Hz to 30 kHz (-3dB). 
Gain 10x (fixed). 
Zero balance Compensation of input offset in the range ±400 mV. 
Buzzer AC feed through microelectrode to assist piercing the cell membrane during microelectrode insertion. The buzz frequency is adjustable with a 16-position switch between 10 Hz and 10 kHz to suit actual equirements. 
Calibration signal Generator for signal adjustment to a computing amplifier or recorder. Pressing the CAL key injects a complex calibration signal consisting of the values 0 Volt, -100 mV and ±50 mV referred to the input. 
Analogue indication LED bargraph with 30 LEDs for visual monitoring of applied signal (7.5 mV per LED referred to input). For accurate zeroing the bargraph range can be expanded by a key (magnifier function) to 1.5 mV per LED referred to input. 
Audio monitor Audible monitoring system for measurement signal using a monitoring tone whose frequency is modulated according to signal amplitude. Loudness and base frequency are individually adjustable by trimmer on the front panel. 
Microelectrode function test Check of microelectrode by feeding in (via the headstage) a constant current for approximate measurement of instantaneous electrode resistance. Since the measurement current may damage the microelectrode by electrolysis the test duration is automatically limited to 2 seconds. 
Supply 5 V 1.2 A from PLUGSYS system bus. 
Dimensions 19" PLUGSYS module, width 12 E (60.96 mm), height 3 U (128.7 mm). 
Weight 400 g. 
Headstage Type 95-1G
Construction Screened metal case with microelectrode holder integral with mounting rod, 2 mm socket for bath reference and screen connection for central ground. The headstage is independent of the MEA amplifier used and does not require adjusting to it. 
Mounting By 8 mm dia. support rod and integral microelectrode holder suitable for mountings of conventional micromanipulators as replacement against the standard microelectrode holder. 
Microelectrode resistance Suitable for microelectrodes in the range 1 to 100 MOhm. 
Input circuit Fully integrated electrometer amplifier with driven screen, boot-strapped supply and capacity compensation. 
Input current compensated to zero. 
Coupling resistor 1 GOhm. 
Capacity compensation Adjustable over 0 – 8 pF 
Frequency range DC to 75 kHz (-3dB) 
Supply From MEA microelectrode amplifier Type 695. 
Connecting cable Signal and supply cable 1.95 m long with 8-pin Binder or Amphenol-Tuchel plug to suit MEA microelectrode amplifier. 
Dimensions Length 140 mm, width 22 mm, height 22 mm.
Weight 160 g.  


HUGO SACHS ELEKTRONIK-HARVARD APPARATUS GmbH
Gruenstrasse 1 · D-79232 March-Hugstetten · GERMANY
Phone: +49 (0) 76 65 - 92 00-0 · Fax: +49 (0) 76 65 - 92 00-90