Isolated Heart Size 5 (Rat, Guinea Pig and Rabbit)
Specifications
|
Body Weight |
Up to 2.5 kg |
|
Heart Diameter |
20 mm |
|
Heart Length (Base - Apex ) |
25 mm |
|
Aorta |
ID Up to 5 mm |
|
Aortic Flow (in WH Mode) |
Up to 500 ml/min |
|
Perfusion Pressure (Afterload) |
Up to 300 mmHg |
|
- High perfusion pressure (up to 300 mmHg); easy and
fast changes of the perfusion pressure (within
seconds)
- Continuous measurement of heart mechanics (contractility,
segment lengths), bioelectrical signals (ECG, MAP) and perfusate
characteristics (pCO2, pO2, pH)
- The system can easily be modified to a working heart system,
the special flow resistance and compliance chamber mimics closely
the in-vivo afterload
- Multiple monophasic action potentials (MAP) and simultaneous
multilead ECG recording from Isolated Perfused Rabbit
heart
- Extended system for hemodynamic and electro-physiology studies
- Applications:
— Dispersion of ventricular repolarization
|
The Isolated Heart Size 5, IH-5, apparatus permits the use
of hearts of small animals (rodents) as well as larger animals
like rabbits. The flow limitation is about 500 ml/min. The perfusate
is oxygenated in a 6 liter water jacketed reservoir with multiple
ports for recircualtion of the perfusate. The system can be
used for work in any one of three methods. The basic system is
the retrograde perfusion mode (Langendorff). By setting a defined
threshold pressure at the flow resistance, the system works under
constant pressure; by increasing the threshold pressure to a supermaximal
pressure (300 mmHg) the system works under constant flow. A working
heart system can be arranged by using the Left Atrium Cannulating
Option. The complete system is mounted on a compact acrylic stand.
The system can also be used to simultaneously record all hemodynamic
parameters as well as 8 MAP-potentials and a 12-lead ECG. For
this purpose, the IH-5 unit is additionally equipped with a circular
holder for 8 MAP-electrodes and with an ECG multi-electrode insert
in the heart chamber.
Checklist for more information
or quotation on
Isolated Heart Systems
HUGO SACHS ELEKTRONIK-HARVARD
APPARATUS GmbH
Gruenstrasse 1 · D-79232 March-Hugstetten · GERMANY
Phone: +49 (0) 76 65 - 92 00-0 · Fax: +49 (0) 76 65 - 92
00-90