- Specific airway resistance measurement together with the standard parameters tidal volume and respiratory rate, in conscious animals
- Can also be used as head-out plethysmograph with aerosol challenge possibility
- Aerosol challenge
- Applications:
- Toxicology
- Environmental studies
- Long term drug effects
The awake animal is placed into the double chamber and is restricted so that the head protrudes into the front chamber. The neck is sealed with a soft diaphragm. The nasal air flow is measured in the front chamber, the thoracic respiratory flow in the rear chamber. Both measurements are made with measurement screens and differential pressure transducers.
There is a phase shift between the two respiratory flows from which the specific airway resistance after PENNOCK is calculated by HSE respiratory software PULMODYN ‘PENNOCK’. The standard parameters like respiratory rate, tidal volume, peak inspiratory and expiratory flow, inspiratory and expiratory duration are evaluated from the flow measured in the thoracal chamber.
The nasal chamber is connected to the bias flow venturi-jet tube (requires stable compressed air, we recommend use of the PLUGSYS module PRM 73-0195 in a housing 73-1520 ), and can be equipped with an aerosol nebulizer and oxygen flushing (supply required). To reduce the handling of valves and switches the PCU Module 73-1748 and 73-1749 can be used.
The thoracic chamber can be removed and the animal can easily be placed into position. The chamber is available in two different sizes to suit different size animals. If only the thoracal chamber is used for measurement, the plethysmograph box is a head-out box with the possibility of aerosol application
