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Setup for Respiratory Studies of Resistance and Compliance with PULMODYN software on Mice

  • 16 channel data acquisition software for in vivo respiration experiments
  • For Windows® 2000, NT and XP
  • Derives and presents online the standard parameters for respiratory studies (TV, Resp. Rate, Resistance, Compliance) real time
  • Possibility of combination with circulatory signals (e.g. arterial and vnous pressure, LVP, aortic flow)
  • In vivo:
    - Bronchodilation test and bronchospasmolytic test on anesthetized animals
    - Antiasthmatics test according to Konzett-Roessler (bronchial overflow measurement) or according to Einthoven (tracheal pressure measurement)
    - Pulmonary air flow
    - Tracheal pressure or esophageal pressure
    - Arterial pressure or venous pressure
    - pO2, pCO2, FiO2, SpO2, ETCO2, pH, temperature etc.

The HSE-HA PULMODYN software can be adapted to virtually any experimental investigation in respiratory experiments. Acquisition can cover signals such as pulmonary air flow, tracheal pressure or esophageal pressure, arterial pressure or venous pressure, pO2, pCO2, pH, temperature etc. Various parameters can be derived from these signals, e.g. tidal volume, respiration rate, peak inspiratory flow, peak expiratory flow, maximal and minimal tracheal pressure, resistance, compliance, systolic, diastolic and mean values for pressures, dp/dt etc. During data acquisition all acquired signals and derived parameters can be displayed on the screen.
The HSE-HA PULMODYN software is available in a basic version which includes the minimal necessary algorithms for pulmonary mechanics evaluation. It can be upgraded to a more complex system including all the available algorithms. The configuration of the system is defined in configuration files to reduce the amount of settings necessary and to ensure a stable and secure system. The user has only to calibrate the signals and to fix the graphics scaling, all the hardware definitions and the algorithms used are defined in the configuration files. This reduces the amount of information necessary in the SOP’s and the possibilities of wrong settings. The configuration files can of course be changed and the software can be used in combination with a set of different configuration files to match the different experiments. PULMODYN is a menu-controlled software and employs special algorithms to calculate the standard pulmonary mechanics parameters.
The HSE-HA PULMODYN software has a maximum of 16 input channels, i.e. up to 16 different raw signals can be handled. The assignment of the signals to the individual channels is determined in the configuration files. The sample rate, the type of signals and the algorithm used for analysis are also defined in the configuration file. The arrangement of the graphic detail (raw signals) and trend (calculated parameters) is defined in the menu.
The HSE-HA Data Acquisition Hardware for PULMODYN W Software is available in three versions:

Hardware Requirements for Pulmodyn:
Both the PLUGSYS and Stand Alone versions require the following computer hardware:
 Computer  PC Pentium at least 500 MHz with one free PCI-slot
 RAM  128 Mbytes or better 256 Mbytes
 Operating System  Windows® 2000/NT or XP
 Hard Disk Space  at least 20 Gbytes
 Floppy Drive  1.44 Mbytes
 CD-ROM Drive  Required
 Monitor  17 or 19”
 Backup Media  MO drive, CD recorder or ZIP drive

Commonly Used Signals for In-Vivo Respiratory Experiments:

The Basic PULMODYN Calculates the Following Parameters On-Line:

  •  From Pulmonary Air Flow
 RespRate, maxInspFl, maxExpFl, TV, dynResistance, Conductance, dynCompl.
  •  From all Pulmonary Pressures
 Maximum, minimum, mean pressure
  •  From Temperature
  Mean value

Additional Software Modules:

  •  Module Advanced Pulm Flow
 Inspiratory time, Expiratory time, Apnea time, Total time, Time of brake, Time of pause, Airflow at 0.5TV
  •  Module for Blood Pressure
 Systolic, diastolic, mean pressure, non-pulsatile mean, Heart Rate
  •  Module to display P-V LOOPS
 
  •  Module for LVP
 LVPsys, LVPedp, dP/dtmax, dP/dtmin, heart rate
  •  Module for ECG
 RR-I, HR


HUGO SACHS ELEKTRONIK-HARVARD APPARATUS GmbH
Gruenstrasse 1 · D-79232 March-Hugstetten · GERMANY
Phone: +49 (0) 76 65 - 92 00-0 · Fax: +49 (0) 76 65 - 92 00-90