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PULMODYN® Pennock forDouble Chamber Plethysmograph Box

This software was especially developed for the investigation of bronchospasmolytically-active substances on conscious animals. In this experiment the awake animal is placed into a double chamber plethysmograph box Type 855, and is restricted so that the head protrudes into the front chamber. The neck is sealed with a soft diaphragm. The nasal air flow is measured in the front chamber, the thoracic respiratory flow in the rear chamber. Both measurements are made with wire-mesh measuring screens and differential pressure transducers. There is a phase shift between the two respiratory flows from which the PULMODYN PENNOCK software calculates the specific airway resistance according to PENNOCK. Data acquisition covers the following signals: pulmonary air flow in the nasal chamber, pulmonary air flow in the thoracic chamber. From the flow signal of the thoracic chamber the following parameters are calculated: respiration rate, tidal volume, maximal inspiratory flow, maximal expiratory flow.
From the phase shift between nasal and thoracic flow phase shift and specific airway resistance are calculated. During data acquisition all acquired signals and derived parameters can be displayed on the screen.
The system covers eight channels. This makes it possible to experiment simultaneously on 4 plethysmograph boxes. All 8 signals are sampled at 1 kHz. This means that each channel is measured 1000 times per second, or measurements on each channel are made once every millisecond. This permits measuring phase shifts of some milliseconds and calculate from this delay the specific airway resistance.
The HSE-HA Data Acquisition Hardware for PULMODYN W Software is available in three versions:

• PLUGSYS Version for direct connection to PLUGSYS System 73-0161, required if PCU module is used for control
• Stand Alone Version 73-0235
• Stand Alone USB Version 73-3330

Hardware Requirements for Pulmodyn Pennock:
Both the PLUGSYS and Stand Alone versions require the following computer hardware:

Computer	PC Pentium at least 500 MHz with one free PCI-slot,
RAM	128 Mbytes or better 256 Mbytes
Operating System	Windows® 2000/NT or XP
Hard Disk Space	at least 20 Gbytes
Floppy Drive	1.44 Mbytes
CD-ROM Drive	Required
Monitor	17 or 19”
Backup Media	MO drive, CD recorder or ZIP drive

The Software Receives the Following Signals from up to 4 Plethysmograph Boxes:

• Airflow from the Nasal Chamber
• Airflow from the Thoracic Chamber
• From these signals the software calculates the following parameters online:

From the Pulmonary Air Flow signals:

• Respiration Rate (RR)
• Peak Inspiratory Flow (PIF), Peak Expiratory Flow (PEF)
• Tidal Volume (TV)
• Optional:
• IT (Inspiratory Time), ET (Expiratory Time), AT (Apnea Time), TT (Total Time), TB (Time of brake), TP (Time of pause), Airflow at 0.5VT

From the Phase Shift between Nasal and Thoracic AirfFlow:

• Phasic Shift in msec (PenSift)
• Specific Airway Resistance (Res)

HUGO SACHS ELEKTRONIK-HARVARD APPARATUS GmbH
Gruenstrasse 1 · D-79232 March-Hugstetten · GERMANY
Phone: +49 (0) 76 65 - 92 00-0 · Fax: +49 (0) 76 65 - 92 00-90