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HSE-HA ISOHEART

16 channel data acquisition software for isolated heart experiments For Windows® NT, 2000, and XP To measure signals such as: perfusion pressure, perfusion flow, left ventricular isovolumetric pressure, aortic pressure, aortic flow, atrial pressure, atrial flow, coronary flow, length measurement, pO2, pCO2, pH, temperature, etc. Easy to use, reduced settings by using configuration files Storage of raw data with possibility for replay. Complete experiments can be replayed Indication of the measured signals and parameters online in numerical tabular form or graphical detail and trend windows Data exchange interface by converting the data into the ASCII delimited format Monitoring of the experimental sequence by placing event markers and concentration information Very easy graphical selection of specific data points by cursors for evaluation, data reduction and export Export of a raw data sequence into ASCII delimited format

The HSE-HA ISOHEART software for Windows can be adapted to virtually any experimental investigation of isolated hearts (according to Langendorff or Working Heart). Acquisition can cover signals such as perfusion pressure, perfusion flow, left ventricular pressure, aortic pressure, aortic flow, atrial pressure, atrial flow, coronary flow, segment length or wall thickness measurement, pO2, pCO2, pH, temperature, etc. Various parameters can be derived from these signals, (e.g., systolic, diastolic, mean and rate (frequency) values for pressures); dP/dt; contractility index CI; minimal, maximal, and mean flows, etc. During data acquisition all acquired signals and derived parameters are stored on the hard disk and can be displayed on the screen.

The HSE-HA ISOHEART software is available in a basic version which includes the minimal necessary algorithms. It can be upgraded to a more complex system including all the available algorithms. The configuration of the system is defined in configuration files to reduce the amount of settings necessary and to ensure a stable and secure system. The user has only to calibrate the signals and to fix the graphics scaling. All the hardware definitions and the algorithms used are defined in the configuration files. This reduces the amount of information necessary in the SOP's and the possibilities of wrong settings. The configuration files can of course be changed and the software can be used in combination with a set of different configuration files to match the different experiments. ISOHEART is a menu-controlled software and employs special algorithms to calculate the standard parameters.

The HSE-HA Data Acquisition Hardware for ISOHEART Software is available in three versions:

• PLUGSYS Version for direct connection to PLUGSYS System
• Stand Alone Version
• Stand Alone Version USB

Hardware Requirements for Haemodyn:

The PLUGSYS and Stand Alone versions require the following computer hardware:

• Computer PC Pentium at least 500 MHz with one free PCI-slot, RAM 128 Mbytes or better 256 Mbytes
• Operating System Windows® 2000/NT or XP
• Hard Disk Space at least 20 Gbytes
• Floppy Drive 1.44 Mbytes
• CD-ROM Drive Required
• Monitor 17 or 19”
• Backup Media MO drive, CD recorder or ZIP drive
  

Commonly Used Signals for Langendorff Preparation are:

• LVP isovolumetric LVP or contraction force
• PP perfusion pressure
• CF coronary flow
• WT wall thickness or left ventricle diameter
• EG electrogram
• pO2a oxygen partial pressure in the affluent
• pO2e oxygen partial pressure in the effluent
• pH pH in the effluent

Commonly Used Signals for Working Heart Preparation are:

• PrP preload pressure
• AoP aortic pressure (afterload)
• LVP left Ventricular Pressure, measured with tip catheter
• AF aortic flow
• CO cardiac output (flow into left atrium)
• WT wall thickness or left ventricle diameter
• EG electrogram
• pO2a oxygen partial pressure in the affluent
• pO2e oxygen partial pressure in the effluent
• pH pH in the effluent

The Basic ISOHEART Calculates the Following Parameters On-Line:

• From LVP Signal: LVPsys, LVPdia, LVPEDP, dP/dtmin, dP/dtmax, Heart Rate, Mean
  Pressure
• From All Pressures: Systolic, Diastolic and Mean Pressure, Heart Rate
• From All Flows: Mean, Max. and Min. Flow
• From Distance: Max., Min. and Amplitude (Max-Min)
• From Electrogram: RR-I, Heart Rate
• From temperature, pO2, pH Signals: Mean Value
• It is also possible to calculate specific values from these parameters
  by writing a formula (e.g., the ratio of dP/dtmin / dP/dtmax or
  LVPEDP / heart weight, etc.).

Additional Software Modules:

• Module LVP Advanced:
  Tau, Time to Peak (Contractility Time), Relaxation Time and
  Contractility Index CI = dP/dtmax / P, Ejection Time
• Module Flow Advanced:
  Endsystolic Flow ESFL, Enddiastolic Flow EDFL
• MAP module:
  Max, Min, Plateau, Amp, Rate, ±dv/dt, duration at 10% of monophasic action potentials
• Dimension module:
  end-systolic length ESL, end-diastolic length EDL, +dL/dt, -dL/dt

HUGO SACHS ELEKTRONIK-HARVARD APPARATUS GmbH
Gruenstrasse 1 · D-79232 March-Hugstetten · GERMANY
Phone: +49 (0) 76 65 - 92 00-0 · Fax: +49 (0) 76 65 - 92 00-90