IPL-1 Core Isolated Perfused Lung System for Mouse

The IPL-1 is an ex vivo lung perfusion system (EVLP) specifically engineered for the fragile mouse lung. The core system can easily be initially configured with various system options of upgraded later are your needs change. 

The core system contains all the primary equipment to accomplish basic perfusion and ventilation experiments, requiring only the addition of core options for ventilation. Application-specific upgrades and options are also available.

Due to the fragile nature of the mouse lung, its suspension from the tracheal and vascular cannulae is difficult to accomplish without the rapid occurrence of edema. In collaboration with experts in pulmonary physiology, a design was developed which allows for ventilation and perfusion with the lungs remaining in situ at a slight incline in the open thorax. This novel approach simplifies cannulation of the pulmonary artery and left atrium of the heart and dramatically reduces edema formation.

The isolated mouse lung can be ventilated under positive pressure and under subatmospheric pressure to mimic the in vivo situation as closely as possible. There are bigger differences in vascular flows seen between positive and negative ventilation. Depending on the study, a ventilated lung or a physiologic breathing lung can be simulated.

Please note: For a functional unit, the core system requires the addition of core system options for ventilation. 

To ensure that your system is properly configured as a functional unit that meets your application needs, please complete our Checklist and contact Technical Services before placing an order. In Europe, please call +49 7665-9200-0 or email sales@hugo-sachs.de. For other regions, call 800-547-6766 or email support@hbiosci.com.

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