Non-Invasive Blood Pressure System for Rodents
Easy and reliable technique to measure systemic blood pressure and cardiovascular parameters in rodents without invasive catheterization.
- Total reliability to realize consecutive measurements on the same animal
- Analog signal output for recording cuff pressure and pulse signals in a PC
- Automated deflation driven separately for each animal (minimize tail lesions)
- Automated cuff inflation/deflation at a very constant rate
- The same system can be used for mouse/rat/dog
- Real values provided (without any linear regression calculation)
- Easily traceable data (using data acquisition software)
- Parameters evaluated can be visualized on-line on the digital display
The Panlab NIPB system provides an easy and reliable technique to measure systemic blood pressure and cardiovascular parameters in rodents without invasive catheterization.
The pulse signal level (heart rate) is continuously monitored on the LCD display while an internal pressure transducer is constantly measuring the current pressure applied on the cuff. Systolic and diastolic blood pressures are displayed after a series of automatic processes finish.
A warm environment is critical for accurate blood pressure measurement. For optimal conditions the Panlab Warming Chamber (76-1137) or the Automatic Heater & Scanner (76-0179) provides a comfortable heated environment. The requirement of a warm environment for the animals is critical for accurate blood pressure measurements. To provide adequate conditions for NIBP measurement, the system can be used in association with a warming chamber which provides a comfortable and heated environment necessary to produce peripheral vasodilatation and isolate the animal from external noise.
Key Features
- Total reliability to realize consecutive measurements on the same animal
- Analog signal output for recording cuff pressure and pulse signals in a PC
- Automated deflation driven separately for each animal (minimize tail lesions)
- Automated cuff inflation/deflation at a very constant rate
- The same system can be used for mouse/rat/dog
- Real values provided (without any linear regression calculation)
- Easily traceable data (using data acquisition software)
- Parameters evaluated can be visualized on-line on the digital display
Parameters Measured
- Systolic blood pressure
- Diastolic blood pressure
- Mean blood pressure
- Heart rate
Included Components
Basic Unit for NIBP 76-0173 (LE5001)
- Control unit with LCD display
- Pressure and pulse BNC analog signal output
- RS-232 serial port
- Cables
- Spare fuses
- Instruction manual
Standard Unit for NIBP 76-0174 (LE5002)
- Includes all components of 76-0173 plus
- Raw data internal memory (up to 4,000 successive trials)
Complete Unit for NIBP 76-0175 (LE5007)
- Includes all components of 76-0174 plus
- Statistical calculations (average, deviation, number of samples for all animals)
- Connection to the Heater and Scanner device for automatic measurement of up to 12 animals
Accessories
- SEDACOM Software*
- Chart™ Software for monitoring of pressure and pulse wave signals
- Single or multiple animal heating units
- Pulse Transducer & Cuff*
- Specimen holders
*Pulse Transducer & Cuff and SEDACOM software must be ordered separately. Requires 76-0608 RS-232/USB adapter.
| Dimensions LE5001 Control Unit | 360 (W) x 340 (D) x 120 (H) mm |
| Dimensions LE5002 and LE5007 Control Units | 60 (W) x 340 (D) x 170 (H) mm |
| Computer Requirements (only if SeDaCom is used) | PC with Windows™ XP (SP2 or higher), Vista 32, Windows 7 or Windows 8 compatible operating system |
| Power Supply | 220/110 VAC, 50/60 Hz |
| Certifications | CE Compliant |
Alfany-Fernandez I et al. Therapeutic Targets in Liver Transplantation: Angiotensin II in Nonsteatotic Grafts and Angiotensin-(1–7) in Steatotic Grafts. Am. J. Transplantation. 2009:9(3)-439- 451.
Bhandari U et al. Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. Fitoterapia. 2008;79(5): 351- 355.
Canicer R et al. Simvastatin reverses the hypertension of heterozygous mice lacking cystathionine α-synthase and apolipoprotein A-I. Naunyn-Schmiedeberg’s Archives of Pharmacology. 2008;377(1):35-43.
Casillas-Ramirez A et al. Inhibition of angiotensin II action protects rat steatotic livers against ischemia-reperfusion injury. Critical Care Medicine. 2008;36(4):1256-1266.
Choi JH et al. Comparative antihypertensive activities of losartan and HM70186 in rats with hepatic dysfunction. Arch. Pharmacal Res. 2009;32(7):1005-1011.
Kim DW et al. (2009) Germinated Buckwheat extract decreases blood pressure and nitrotyrosine immunoreactivity in aortic endothelial cells in spontaneously hypertensive rats. Phytotherapy Research. 2009;23(7):993-998.
Ramalho FS et al. Are Angiotensin II Receptor Antagonists Useful Strategies in Steatotic and Nonsteatotic Livers in Conditions of Partial Hepatectomy under Ischemia-Reperfusion? J. Pharmacol. Exp. Ther. 2009;329:130-140.