Study of Food and Drink & Metabolism
Assessment of metabolic responses, such as measurement of O2 consumption/CO2 production, food/drink intake, is particularly relevant in the field of obesity investigation. However, metabolic responses are also modulated in many conditions, such as disease or stress.
Knowledge in the field of animal energetics is largely based upon indirect calorimetry, which is estimation of metabolic heat production by the organism from measurement of indices such as oxygen consumption or carbon dioxide production. This technique is broadly used to study mechanisms of energy intake and expenditure in obesity, anorexia or diabetes rodent models.
With actual major health problems linked to food and drink intakes such as alcoholism and obesity, the search to define the role of brain and molecular mechanisms in regulating food and drink intake has taken on a new priority. In this way, a precise monitoring of food and drink intake is necessary to evaluate fine alterations of these functions, in response to treatments, brain lesions or in transgenic animals.
Forced exercise in a treadmill test in rodents is also a useful tool with a great value in the study of functional capacity and is a validated standard model for investigations in the field of human metabolism. This test allows the study of various physiological and behavioral functions such as long and short-term effort during exercise, metabolic exchanges, cardiac function, motor coordination and fatigue in rodents.